General Medicine

Study Title
Healthcare via Cell Phones: A Systematic Review

Study Group
Review of 25 studies that evaluated cell phone voice and text messaging interventions, with 20 randomized controlled trials and 5 controlled studies. Nineteen studies assessed outcomes of care and six assessed processes of care.

Reminder Type
SMS, Phone

Summary
Significant improvements were noted in compliance with medicine taking, asthma symptoms, HbA1C, stress levels, smoking quit rates, and self-efficacy. Process improvements were reported in lower missed appointments, quicker diagnosis and treatment, and improved teaching and training.

Citation
Santosh Krishna; Suzanne Austin Boren; E. Andrew Balas; "Healthcare via Cell Phones: A Systematic Review,Telemedicine and e-Health," 15(3) (April 21, 2009); 231-240.DOI:10.1089/tmj.2008.0099
http://science.icmcc.org/2009/04/22/healthcare-via-cell-phones-a-systematic-review/

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Study Title
Adherence to Medication

Study Group
Review Article

Summary

Patients who have difficulty maintaining adequate adherence need more intensive strategies than do patients who have less difficulty with adherence, a more forgiving medication regimen, or both. Innovative methods of managing chronic diseases have had some success in improving adherence when a regimen has been difficult to follow. New technologies such as reminders through cell phones and personal digital assistants and pillboxes with paging systems may be needed to help patients who have the most difficulty meeting the goals of a regimen.

Citation
Osterberg, Lars M.D. and Blaschke, Terrence M.D.,“Adherence to Medication,” The New England Journal of Medicine, N Engl J Med 2005; 353 (August 4, 2005): 487-497.
http://content.nejm.org/cgi/content/extract/353/5/487

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Study Title
Prescription Drug Compliance a Significant Challenge for Many Patients

Study Group
Survey

Summary
Nearly two-thirds (64%) of 2,507 US adults report that they have simply forgotten to take their medication, with 11 percent saying that this has happened "often" or "very often."

Citation
“Prescription Drug Compliance a Significant Challenge for Many Patients," Harris Interactive/The Wall Street Journal March 29, 2005
http://www.marketresearchworld.net/index.php?option=com_content&task=view&id=289&Itemid=48

Study Title

Impact of Medication Adherence on Hospitalization Risk and Healthcare Risk and Healthcare Cost

Study Group
Prospective cohort observation, 137,277 patients under age 65

Summary
The objective of this study was to evaluate the impact of medication adherence on healthcare utilization and cost for four chronic conditions that are major drivers of drug spending: diabetes, hypertension, hypercholesterolemia, and congestive heart failure. For diabetes and hypercholesterolemia, higher medication costs were more than offset by medical cost reductions, producing a net reduction in overall healthcare costs. For diabetes, hypercholesterolemia, and hypertension, cost offsets were observed for all-cause medical costs at high levels of medication adherence. For all four conditions, hospitalization rates were significantly lower for patients with high medication adherence.

Citation
Sokol, Michael C. MD, MS; McGuigan, Kimberly A. PhD; Verbrugge; Robert R. PhD, and Epstein, Robert S. MD, "Impact of Medication Adherence on Hospitalization Risk and Healthcare Risk and Healthcare Cost,” Med Care,43: (2005);521–530
http://www.ncbi.nlm.nih.gov/pubmed/15908846

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Study Title
Use of Reminders for Preventive Procedures in Family Medicine

Study Group
Prospective, randomized, controlled study. 8,502 patients 15 years of age or more

Reminder Type
Phone

Summary
Computerized reminder systems do improve the delivery of preventive services in family practice. Note that telephone reminders were significantly more effective than letter reminders among men 15-44 years.

Citation
Rosser, William MD; McDowell, Ian PhD; Newell, Claire MA,“ Use of Reminders for Preventive Procedures in Family Medicine,” Canadian Medical Association Journal,145 (7): (1991) 807-814
http://www.cmaj.ca/cgi/content/abstract/145/7/807

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Study Title
A Meta-analysis of l6 Randomized Controlled Trials to Evaluate Computer-based Clinical Reminder Systems for Preventive Care in the Ambulatory Setting

Study Group
Meta-analysis

Reminder Type
Computer-based

Summary
Evidence from randomized controlled studies supports the effectiveness of data-driven computer-based reminder systems to improve prevention services in the ambulatory care setting.

Citation
Shea, Steven MD; Dumouchel, William PhD; Bahamonde, Lisa BA; “A Meta-analysis of l6 Randomized Controlled Trials to Evaluate Computer-based Clinical Reminder Systems for Preventive Care in the Ambulatory Setting,” Journal of the American Medical Informatics Association, Volume 3 Number 6, (Nov / Dec 1996), 399-409.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=116324

Role of Cell Phone Reminders for Patients Forgetting to Take Medication

Of the 63% of adults who have had prescription drugs prescribed to them in the last year -- drugs which are to be taken regularly -- nearly two-thirds (64%) report that they have simply forgotten to take their medication."